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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TNKS
All Species:
28.18
Human Site:
Y486
Identified Species:
51.67
UniProt:
O95271
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95271
NP_003738.2
1327
142039
Y486
E
L
R
E
R
L
T
Y
E
F
K
G
H
S
L
Chimpanzee
Pan troglodytes
XP_001137443
1327
142033
Y486
E
L
R
E
R
L
T
Y
E
F
K
G
H
S
L
Rhesus Macaque
Macaca mulatta
XP_001090358
1327
142132
Y486
E
L
R
E
R
L
T
Y
E
F
K
G
H
S
L
Dog
Lupus familis
XP_849388
1327
142003
Y486
E
L
R
E
R
L
T
Y
E
F
K
G
H
S
L
Cat
Felis silvestris
Mouse
Mus musculus
NP_780300
1320
140926
Y479
E
L
R
E
R
L
T
Y
E
F
K
G
H
S
L
Rat
Rattus norvegicus
NP_001101077
1166
126761
V406
E
F
L
T
P
L
H
V
A
S
E
N
A
H
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508887
1320
142724
Y479
E
L
R
E
R
L
T
Y
E
F
K
G
H
S
L
Chicken
Gallus gallus
Q5F478
990
107379
V230
K
H
L
L
N
L
G
V
E
I
D
E
M
N
I
Frog
Xenopus laevis
NP_001088420
1303
140252
Y462
E
L
K
E
R
L
S
Y
E
F
K
G
H
S
L
Zebra Danio
Brachydanio rerio
Q502K3
1071
114412
H311
K
E
G
K
S
P
L
H
M
A
A
I
H
G
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651410
1181
127927
V417
L
H
Y
D
A
M
E
V
L
L
K
Q
G
A
K
Honey Bee
Apis mellifera
XP_396483
1166
127309
T406
L
T
P
L
H
V
A
T
D
H
S
H
Y
D
A
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001186587
1157
126547
N397
G
A
N
L
L
D
K
N
N
D
G
L
A
P
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
99.6
98.9
N.A.
96.5
72.2
N.A.
86.8
23.2
87.1
21.8
N.A.
59.4
62.7
N.A.
63.6
Protein Similarity:
100
99.6
99.7
99.1
N.A.
97
80.3
N.A.
89.1
37.4
90.9
37.3
N.A.
71.7
72.8
N.A.
74.6
P-Site Identity:
100
100
100
100
N.A.
100
13.3
N.A.
100
13.3
86.6
6.6
N.A.
6.6
0
N.A.
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
20
N.A.
100
33.3
100
26.6
N.A.
26.6
20
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
8
0
8
0
8
8
8
0
16
8
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
0
8
0
0
8
8
8
0
0
8
0
% D
% Glu:
62
8
0
54
0
0
8
0
62
0
8
8
0
0
0
% E
% Phe:
0
8
0
0
0
0
0
0
0
54
0
0
0
0
0
% F
% Gly:
8
0
8
0
0
0
8
0
0
0
8
54
8
8
0
% G
% His:
0
16
0
0
8
0
8
8
0
8
0
8
62
8
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
8
0
8
0
0
8
% I
% Lys:
16
0
8
8
0
0
8
0
0
0
62
0
0
0
8
% K
% Leu:
16
54
16
24
8
70
8
0
8
8
0
8
0
0
62
% L
% Met:
0
0
0
0
0
8
0
0
8
0
0
0
8
0
0
% M
% Asn:
0
0
8
0
8
0
0
8
8
0
0
8
0
8
8
% N
% Pro:
0
0
8
0
8
8
0
0
0
0
0
0
0
8
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% Q
% Arg:
0
0
47
0
54
0
0
0
0
0
0
0
0
0
8
% R
% Ser:
0
0
0
0
8
0
8
0
0
8
8
0
0
54
0
% S
% Thr:
0
8
0
8
0
0
47
8
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
8
0
24
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
54
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _